Yes, we are proud of our record in research
and publication at Genesis...

Publications:

Daniluk J, Fluker MR. Fertility drugs and the reproductive imperative: Assisting the infertile woman. Women & Therapy 1995;16:31-47.

Fluker MR, Tiffin GJ. Assisted Reproductive Technologies - A Primer for Canadian Physicians. J Soc Obstet Gynecol 1996;18:451-65.

Fluker MR, Wang IY, Rowe TC. An extended 10-day course of clomiphene citrate (CC) in women with CC-resistant ovulatory disorders. Fertil Steril 1996 Nov;66(5):761-4.

Ludwin S, Low JA, Fisher S. Neuropathy associated with severe fetal asphyxia. American Journal of Obstetrics and Gynecology 1996; 175(5): 1383-5.

Reid RL, Hahn PM, Spence JE, Tulandi T, Yuzpe AA, Wiseman DM. A randomized clinical trial of oxidized regenerated cellulose adhesion barrier (Interceed, TC7) alone or in combination with heparin. Fertil Steril 1997;67(1):23-9.

Hornstein MD, Yuzpe AA, Burry K, Buttram VC, Heinrichs L, Soderstrom RM, Steinberger E, Lin J. Retreatment with nafarelin for recurrent endometriosis symptoms: Efficacy, safety, and bone mineral density. Fertil Steril 1997;67(6):1013-18.

Rioux J, Yuzpe AA. Modern approaches to female sterilization: A brief of the history of laparoscopic sterilization is in order, to better understand where we should be going in the light of our current knowledge. Contemp Ob Gyn 1997;42(9):92-3.

Hornstein MD,Hemmings R, Yuzpe AA, Heinrichs WL. Use of nafarelin versus placebo after reductive laparoscopic surgery for endometriosis. Fertil Steril 1997;68(5):860-4.

Fitzsimmons BP, Bebbington MW, Fluker MR. Perinatal and neonatal outcomes in multiple gestations: Assisted reproduction versus spontaneous conception. Am J Obstet Gynecol 1998 Nov;179(5):1162-1167.

Belisle S, Fluker MR and the Consensus Conference Writing Group. Canadian Consensus Conference on Menopause and Osteoporosis. J Soc Obstet Gynecol 1998;20:1243-72 (part I) and 1998;20:1348-82 (part II).

Fluker MR, Hooper WM, Yuzpe AA. Withholding gonadotropins ("coasting") to minimize the risk of ovarian hyperstimulation during superovulation and in vitro fertilization-embryo transfer cycles. Fertil Steril 1999 Feb;71(2):294-301.

Yuzpe AA, et al. The Canadian Consensus Conference on Endometriosis. In: Rowe TC, ed. JOGC 1999:21;468-98.

Al-Badawi IA, Fluker MR, Bebbington MW. Diagnostic laparoscopy in infertile women with a normal hysterosalpingogram. J Reprod Med 1999;44:953-7.

Winsor S, Fisher S, Hahn P, Reid RL. Retrospective evaluation of long-term outcomes following medical management of menorrhagia in ovulatory women. Journal SOGC 1999; 21(2): 155-63.

Yuzpe AA. Commentary – Very low doses of mifepristone were as effective for emergency contraception as the higher dose. Evidence-based Obstetrics and Gynecology 2000;2:70.

Elliott S, Fluker MR. Fertility options for men with ejaculatory disorders. J Soc Obstet Gynecol 2000;22:26-32.

Fluker MR, Copeland JE, Yuzpe AA. An ounce of prevention: Outpatient management of ovarian hyperstimulation syndrome. Fertil Steril 2000;73:821-4.

Stephenson MD, Fluker MR. Treatment of repeated unexplained IVF failure with intravenous immunoglobulin: A randomized placebo-controlled Canadian trial. Fertil Steril 2000;74:1108-13.

Fluker, MR. Gonadotropin-releasing hormone antagonists. Curr Opin Endocrinol Diab 2000;7:350-6.

Yuzpe, AA, Liu Z, Fluker MR. Rescue intracytoplasmic sperm injection (ICSI) – salvaging in vitro fertilization (IVF) cycles after total or near-total fertilization failure. Fertil Steril 2000; 73:1115-19.

Fluker MR, Yuzpe AA. Partial Hydatidiform mole following transfer of a cryopreserved-thawed blastocyst. Fertil Steril 2000;74:828-9.

Fisher S, Davies GA, Mackenzie VP. Double blind randomized controlled trial of oral versus vaginal misoprostol for induction of labor. American Journal of Obstetrics and Gynecology 2001; 185(4): 906-10. Presented at the Society for Maternal Fetal Medicine Annual Meeting, Reno, Nevada, February 5-11, 2001.

The North American Ganirelix Study Group – Fluker MR, Grifo J, Leader A, Levy M, et al. Efficacy and safety of ganirelix acetate versus leuprolide acetate in women undergoing controlled ovarian hyperstimulation. Fertil Steril 2001;75:38-45.

Liu Z, Fluker MR, Nigro M, Elliott S, Yuzpe AA. Fertilization rates, embryo development and pregnancy rates after intracytoplasmic sperm injection (ICSI) using epididymal and testicular sperm. JOGC 2001;23:576-80.

Fluker, MR. HRT in older women – Is it ever too late? BC Med J 2001;43:459-62.

Montemuro, S, Fluker MR, Rogers J, Derzko C. The Canadian Consensus Conference on Menopause and Osteoporosis – Healthy Living. JOGC 2001;23:842-8.

Johnston SL, Graves GR, Kendler DL, Fluker MR. The Canadian Consensus Conference on Menopause and Osteoporosis – Medical and Special Conditions. JOGC 2001;23:1097-1101.

Fluker MR, Montemuro S. The Canadian Consensus on Menopause and Osteoporosis – Complementary Approaches. Obstet Gynecol 2001;23:1204-1213.

Claman P, Graves GR, Kredentser JV, Sagle M, Tan S, Tummon I, Fluker MR. SOGC Clinical Practice Guidelines. Hirsutism: evaluation and treatment. JOGC 2002;24:62-73.

Hughes EG, Beecroft ML, Wilkie V, Burville L, Claman P, Tummon I, Greenblatt E, Fluker MR, Thorpe K. A multicentre randomized controlled trial of expectant management versus IVF in women with fallopian tube patency. Hum Reprod 2004;19:1105-9.

Bretherick KL, Fluker MR, Robinson WP. FMR1 repeat sizes in the gray zone and high end of the normal range are associated with premature ovarian failure. Hum Genet 2005;117:376-82.

Tan SL, Child TJ, Cheung AP, Fluker MR, Yuzpe AA, Casper R, Leung P, Cadesky K, Davis VJ. A randomized, double-blind, multicentre study comparing a starting dose of 100 IU or 200 IU or recombinant follicle stimulating hormone (Puregon) in women undergoing controlled ovarian hyperstimulation for IVF treatment. J Assist Reprod Gen 2005;22:81-8.

Lambalk CB, Leader A, Olivennes F, Fluker MR, Nyboe Anersen A, Ingerslev J, Khalaf Y, Avril C, Belaish-Allart J, Roulier R, Mannaerts B. Treatment with the GnRH antagonist ganirelix prevents premature lutenization and ovulation in stimulated intrauterine insemination (IUI): results of a placebo-controlled, double-blind multicentre trial. Hum Reprod: 2006;21:632-9).

Bretherick KL, Metzger D, Chanione JP, Panagiotopoulos C, Watson SK, Lam WL, Fluker MR, Brown CJ, Robinson WP. Skewed X-chromosome inactivation is associated with primary but not secondary ovarian failure. Am J Med Genet A 2007;143:945-51.

Bretherick KL, Hanna CW, Currie LM, Fluker MR, Hammond GL, Robinson WP. Estrogen receptor a gene polymorphisms are associated with idiopathic premature ovarian failure. (accepted, Fertil Steril 2007)

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Presentations at Scientific Meetings by members of the Genesis staff:

Hooper WM, Fluker MR, Yuzpe AA. Viable oocytes in spite of a deliberate and marked reduction in serum estradiol levels during IVF treatment cycles. Poster presentation. Annual meeting of the Canadian Fertility and Andrology Society; 1996 Nov 20-23: Lake Louise, AB.

Fluker MR, Yuzpe AA. Coasting (withholding gonadotropins) as a method of rescuing over-stimulated superovulation cycles. Poster presentation. Annual meeting of the Canadian Fertility and Andrology Society; 1996 Nov 20-23: Lake Louise, AB.

Getsios S, Stephenson MD, Fluker MR, Blaschuk OW, MacCalman CD. The cadherin subtypes present in the human endometrium are spatiotemporally expressed during the menstrual cycle. Poster presentation. Annual Meeting of the Canadian Fertility and Andrology Society; 1996 Nov 20-23: Lake Louise, AB.

Chen GTC, Furth EE, Fluker MR, MacCalman CD. Cadherin-II is spatiotemporally expressed in the human ovary. Poster presentation. 10 th World Congress on IVF and Assisted Reproduction; 1997 May 24-28: Vancouver, BC.

Al-Badawi I, Fluker MR, Bebbington MW. The role of diagnostic laparoscopy in the investigation of infertile women with a normal hysterosalpingogram (HSG). Paper presentation. Annual meeting of the Society of Obstetricians and Gynecologists of Canada; 1997 June 20-25, Halifax, NS. (runner-up for prize paper)

Fitzsimmons B, Bebbington MW, Fluker MR. Perinatal and neonatal outcomes in multiple pregnancies - spontaneous vs. assisted reproduction. Poster presentation. Annual Meeting of the Society of Perinatal Obstetricians; 1998 Feb 2-7, Miami Beach, FLA.

Copeland JE, Yuzpe AA, Fluker MR. Converting from controlled ovarian hyperstimulation (COH) to in vitro fertilization (IVF). Oral presentation. 54th Annual meeting of the American Society of Reproductive Medicine; 1998 Oct 4-8, San Francisco, CA.

Liu Z, Nigro M, Elliott S, Berardinucci D, Fluker MR, Yuzpe AA. Fertilization rates, embryo development and pregnancy rates after intracytoplasmic sperm injection using ejaculated and epididymal sperm. Oral presentation. 54th Annual meeting of the American Society of Reproductive Medicine; 1998 Oct 4-8, San Francisco, CA.

Baker W, Copeland J, McKeachie S, Fluker MR, Yuzpe AA. Choosing a sperm donor: Comparison of preferred characteristics by recipient marital status and sexual orientation. Poster presentation. 54th Annual meeting of the American Society of Reproductive Medicine; 1998 Oct 4-8, San Francisco, CA.

Stephenson MD, Houlihan E, Fluker MR. Treatment of unexplained repeated in vitro fertilization failure with intravenous immunoglobulin: A randomized clinical trial. Oral presentation. Annual Meeting of the Society for Gynecologic Investigation; 1999 Mar 11-14, Atlanta, GA.

Copeland JE, Fluker MR, Yuzpe AA. The nurse's role in office transvaginal drainage (TVD) of ascites in ovarian hyperstimulation syndrome (OHSS): A method of avoiding hospitalization. Oral presentation. Conjoint Annual Meeting of the American Society for Reproductive Medicine and the Canadian Fertility and Andrology Society; 1999 Sept 25-30, Toronto, Ont.

Liu Z, Fluker MR, Yuzpe AA. Outcome of fresh and cryopreserved embryos derived from rescue-ICSI cases of IVF fertilization failure. Oral presentation. Conjoint Annual Meeting of the American Society for Reproductive Medicine and the Canadian Fertility and Andrology Society; 1999 Sept 25-30, Toronto, Ont.

Agameya A, Fluker MR, Leader A, Claman P, Yuzpe AA. Impact of a GhRH antagonist on the endometrium in women undergoing IVF. Oral presentation. Conjoint Annual Meeting of the American Society for Reproductive Medicine and the Canadian Fertility and Andrology Society; 1999 Sept 25-30, Toronto, Ont.

Feigenbaum SL, Fluker MR. Human embryonic heart rates measured by ultrasound progressively rise three fold and rapidly in earliest gestation: Normative Data. Poster presentation. Conjoint Annual Meeting of the American Society for Reproductive Medicine and the Canadian Fertility and Andrology Society; 1999 Sept 25-30, Toronto, Ont.

Fluker MR, Copeland JE, Yuzpe AA. A prospective randomized clinical trial of four fixed starting doses of recombinant FSH in women undergoing ovarian stimulation for IVF. Oral presentation. Annual Meeting of the European Society of Human Reproduction and Embryology; 2000 26-29 June, Bologna, Italy.

Copeland JE, Fluker MR, Yuzpe AA. Flare versus mid-luteal phase down-regulation in women over 40 – Is there a difference? Oral presentation (O-015). 56 th Annual Meeting of the American Society for Reproductive Medicine; 2000 Oct 21-26, San Diego, CA.

Baker W, Chow CJ, Yuzpe AA, Fluker MR. Comparison of semen characteristics and pregnancy rates using washed versus unwashed donor sperm for Intrauterine Insemination. Oral presentation (O-016). 56 th Annual Meeting of the American Society for Reproductive Medicine; 2000 Oct 21-26, San Diego, CA.

Glass KB, Greene CA, Fluker MR, Schoolcraft WB, McNamee PI, Meldrum DR. Multicenter randomized controlled trial of cervical irrigation at the time of embryo transfer. Oral presentation (O-085). 56 th Annual Meeting of the American Society for Reproductive Medicine; 2000 Oct 21-26, San Diego, CA.

Pierson RA, Archer DF, Moreau M, Audet M-C, Fluker MR, Bouchard C. A contraceptive patch is significantly more effective than oral contraceptives in suppressing follicular development. Oral presentation (O-086). 56 th Annual Meeting of the American Society for Reproductive Medicine; 2000 Oct 21-26, San Diego, CA.

Liu Z, Fluker MR, Yuzpe AA. Towards transferring fewer embryos. Poster presentation (P-164). 56 th Annual Meeting of the American Society for Reproductive Medicine; 2000 Oct 21-26, San Diego, CA.

Mortimer ST, Fluker MR, Yuzpe AA. Effect of culture conditions on embryo cleavage rates and morphology. Poster presentation (FP2). Annual Meeting of the Canadian Fertility and Andrology Society; 2001 Oct 4-6: Whistler, BC.

Mortimer ST, Fluker MR, Yuzpe AA, Mortimer D. Keeping the lab in control – Use of laboratory performance measures. Poster presentation. Annual Meeting of the Canadian Fertility and Andrology Society; 2001 Oct 4-6: Whistler, BC.

McKeachie S, Copeland JE, Fluker MR, Yuzpe AA. Discounted fee structures for IVF/ICSI cycles in centers across Canada. Poster presentation (FP11). Annual Meeting of the Canadian Fertility and Andrology Society; 2001 Oct 4-6: Whistler, BC.

Copeland JE, Fluker MR, Yuzpe AA. Moderate to severe ovarian hyperstimulation syndrome (OHSS): the patient’s experience. Poster presentation (FP13). Annual Meeting of the Canadian Fertility and Andrology Society; 2001 Oct 4-6: Whistler, BC.

Mortimer ST, Hillis AJ, Fluker MR, Yuzpe AA (2002) Sperm function tests in management of clinical assisted reproductive technology. 18th Annual Meeting of the European Society of Human Reproduction and Embryology, July 2002,Vienna,. Hum. Reprod., 17 (Abstract Book 1): Abstract P-317, p 110 .

Mortimer ST , Fluker MR, Yuzpe AA (2002) Impact of cleavage rate upon the implantation potential of day 3 embryos. Poster presentation (FP-22). 48th Annual Meeting of the Canadian Fertility and Andrology Society, 2002 September 25–28: Charlevoix, Quebec..

Mortimer S, Fluker MR, Yuzpe AA. Effect of culture conditions on embryo cleavage rates and morphology. Poster presentation (FP2) at the Annual Meeting of the Canadian Fertility & Andrology Society; 2001 Oct 4-6: Whistler, BC.

Copeland JE, Fluker MR, Yuzpe AA. Assisted reproduction for HIV infected patients: current practices and attitudes of paramedical staff. Oral presentation (0-194) 58th Annual Meeting of the American Society of Reproductive Medicine; 2002 Oct 12-17: Seattle, Wa.

Mortimer ST , Fluker M, Yuzpe A (2002) Effect of embryo transfer catheter on implantation rates. 58th Annual Meeting of the American Society for Reproductive Medicine, October 2002, Seattle. Fertil. Steril., 76:3S Abstract O-045, p S17.

Mortimer ST , Maia N, Fluker MR, Yuzpe AA. Cumulus-oocyte complex assessment predicts early embryonic competence. Poster presentation, Annual Meeting of the European Society of Human Reproduction & Embrology, 2003 June 30-July 3, Madrid, Spain.

Mortimer ST, Fluker MR, Yuzpe AA. Effect of culture system upon fertilization rate and embryo development for patients 40 years and older. Poster presentation (P-140), 59th Annual Meeting of the American Society for Reproductive Medicine, 2003 October 11-15, San Antonio, TX.

Hughes EG, Beecroft ML, Claman P, Tummon I, Greenblatt E, Fluker MR. A multicenter randomized controlled trial of expectant management vs in vitro fertilization (EMVI) in women with fallopian tube patency. Oral presentation (O-190), 59th Annual Meeting of the American Society for Reproductive Medicine, 2003 October 11-15, San Antonio, TX.

Tan SL, Child TJ, Cheung P, Fluker MR, Casper R, Davis V. A randomized, assessor-blind multicentre study to investigate the efficacy and efficiency of a starting dose of 100 IU or 200 IU of recombinant follicle stimulating hormone (Puregon) in women undergoing controlled ovarian hyperstimulation for in vitro fertilzation-embryo transter treatment. Poster presentation (P-190), 59th Annual Meeting of the American Society for Reproductive Medicine, 2003 October 11-15, San Antonio , TX .

Bretherick KL, Fluker MR, Beever C, Anderson C, Brown CJ, Robinson WP. Skewed X-chromosome inactivation in premature ovarian failure. Poster presentation (P-0883), 53rd Annual Meeting of the American Society of Human Genetics, 2003 November 4-8, Los Angeles , CA .

McKeachie S, Copeland J, Fluker MR, Yuzpe AA. (2003) Exploring the reasons why women wait to attempt pregnancy and/or seek fertility treatment. Poster presentation. 49 th Annual Meeting of the Canadian Fertility and Andrology Society, 2003 November 5-8, Victoria, BC.

Fisher S , Grin A, Palto A, Shapiro H. The Effect of Falling Estradiol Levels Prior to HCG on IVF Outcome. Presented at Canadian Fertility and Andrology Society Annual Meeting, Nov 5-9, 2003, Victoria, B.C. Submitted for publication.

Grin A, Dwyer C, Fisher S, Shapiro H. Use of the GnRH Antagonist Ganirelix Prior to Sperm Wash Conversion to IVF. Presented at Canadian Fertility and Andrology Society Annual Meeting, Nov 5-9, 2003, Victoria, B.C. Submitted for publication.

Mellon J, Kelk D, Fluker MR, Yuzpe AA (2004) Comparison of day 3 versus blastocyst transfer related to maternal age. Abstract Poster presentation, 60 th Annual Meeting of the American Society of Reproductive Medicine, 2004 October 16 – 20, Philadelphia, Pennsylvania.

Mellon J, White D, Fluker MR, Yuzpe AA. (2004) Investigations of pregnancies in patients aged 40 years and over. Poster presentation, 50th Annual Meeting of the Canadian Fertility and Andrology Society , 2004 November 24-27, Jasper, Alberta.

Liu Z, Fluker MR, Mellon J, Maia N, Yuzpe AA. (2004) Follow-Up Study of Early Rescue-ICSI. Poster presentation, 50th Annual Meeting of the Canadian Fertility and Andrology Society, 2004 November 24-27, Jasper, Alberta.

McDonald H, Copeland J, White D, Fluker MR, Yuzpe AA. (2004) Luteul support for IVF and ICSI pregnancies. When is Enough Enough?. Poster presentation, 50th Annual Meeting of the Canadian Fertility and Andrology Society, 2004 November 24-27, Jasper, Alberta.

Bretherick KL, Fluker MR, Robinson WP. Hormone receptor variants and premature ovarian failure. Poster presentation, European Society of Human Genetics Annual Meeting, 2005 May 7-10, Prague.

Courtney GG, Copeland JE, Racette N, Yuzpe AA, Fluker MR. Pregnancy outcome following use of hydroxyethyl starch (HES), human albumin (ALB) or no colloid infusion in women undergoing paracentesis for ovarian hyperstimulation syndrome (OHSS). Oral presentation (S65), 61st Annual Meeting of the American Society for Reproductive Medicine, 2005 October 17-19, Montreal, PQ.

Mellon JA, Salvador CJ, Fluker MR, Yuzpe AA, Kelk DA. A randomized prospective comparison of a sequential versus single media culture system. Poster presentation (S449-450), 61st Annual Meeting of the American Society for Reproductive Medicine, 2005 October 17-19, Montreal, PQ.

Bretherick KL, Fluker MR, Brown CJ, Robinson WP. X chromosome DNA methylation: a new quantitative assay & preliminary results in women with premature ovarian failure. Poster presentation, American Society of Human Genetics, 2006 October 9-13, New Orleans, LA.

Liu Z, Fluker MR, Yuzpe AA, Racette N, Kelk DA. Combining early rescue-ICSI with day-4 embryo transfer. Oral presentation (O-145), 62nd Annual Meeting of the American Society for Reproductive Medicine, 2006 October 21-26, New Orleans, LA.

Book Chapters:

Daniluk J, Fluker MR. Fertility drugs and the reproductive imperative: Assisting the infertile woman. In: Hamilton JA and Jensvold M, editors. Psychopharmacology from a Feminist Perspective. New York Harrington Press. 1995:31-47

Fluker MR. Ovulation Induction with Clomiphene Citrate. In: Homburg R, editor. Ovario Poliquistico (Polycystic Ovary Syndrome), Cuadernos de Medicina Reproductiva. Madrid, Editorial Medica Panamericana, SA, 1998:151-62

Fluker MR. Ovulation Induction with Clomiphene Citrate. In: Homburg R, editor. Polycystic Ovary Syndrome. London, Martin Dunitz Publishers 2000:119-28

Fluker MR, Fisher S. Anovulation and Ovulatory Dysfunction. In: Falcone T and Hurd W, editors. Clinical Reproductive Medicine and Surgery, Philadelphia, Elsevier Inc. 2007.

Fluker MR. Outpatient management of patients with OHSS. In: Gerris J, Olivennes F and Delvigne P, editors. Ovarian Hyperstimulation Syndrome. Taylor & Francis Medical Books, London. 2006.

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